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In other tissues, including the liver, skeletal muscle and macrophages, genetic disruption of clock genes has also been linked to changes in CI, CII and CIII respiration 6,37,38,39,40,41,42,43 , highlighting that clock regulation of mitochondrial function is shaped by cell type and metabolic state

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This study shows that a new pathophysiological model is scientifically mature, as basis for a new type of treatment of depression and, probably, of other psychiatric disorders, which replaces the old reductionist model and the standard therapy, even of a combined type (pharmacotherapy and psychotherapy together), which is of little efficacy